- CasNo120014-30-4
- Purity99%
Location:Home > Pharmaceutical
Quality manufacturer supply 5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one 120014-30-4 in stock with high standard
- Molecular Formula:C17H23NO3
- Molecular Weight:289.375
- Vapor Pressure:0mmHg at 25°C
- Melting Point:258-260°C (dec.)
- Refractive Index:1.538
- Boiling Point:454.109 °C at 760 mmHg
- PKA:10.57±0.10(Predicted)
- Flash Point:228.437 °C
- PSA：47.56000
- Density:1.116 g/cm3
- LogP:2.77730
5,6-Dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one(Cas 120014-30-4) Usage
InChI:InChI=1/C17H23NO3/c1-20-15-9-12-8-13(7-11-3-5-18-6-4-11)17(19)14(12)10-16(15)21-2/h9-11,13,18H,3-8H2,1-2H3
120014-30-4 Relevant articles
Synthesis, molecular docking studies, and antimicrobial evaluation of new structurally diverse ureas
Patil, Mahadev,Poyil, Anurag Noonikara,Joshi, Shrinivas D.,Patil, Shivaputra A.,Patil, Siddappa A.,Bugarin, Alejandro
, p. 302 - 311 (2019)
A series of new urea derivatives (3a-p) ...
Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase
Renou, Julien,Dias, José,Mercey, Guillaume,Verdelet, Tristan,Rousseau, Catherine,Gastellier, Anne-Julie,Arboléas, Mélanie,Touvrey-Loiodice, Mélanie,Baati, Rachid,Jean, Ludovic,Nachon, Florian,Renard, Pierre-Yves
, p. 17929 - 17940 (2016)
Poisoning by organophosphorus nerve agen...
Two novel donepezil-lipoic acid hybrids: Synthesis, anticholinesterase and antioxidant activities and theoretical studies
Terra, Bruna S.,Da Silva, Pedro H. C.,Tramarin, Anna,Franco, Lucas L.,Da Cunha, Elaine F. F.,Macedo, Fernando,Ramalho, Teodorico C.,Bartolini, Manuela,Bolognesi, Maria L.,De Fátima, ?ngelo
, p. 738 - 747 (2018)
Alzheimer disease (AD) is a complex dise...
Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors
Gonzalez, Michael,Hudson, Paula K.,Lorzadeh, Shahrokh,Makarian, Makar,Pecic, Stevan,Salvador, Stephanie M.
, (2021/09/14)
In an effort to develop new therapeutic ...
Polysilane-Immobilized Rh-Pt Bimetallic Nanoparticles as Powerful Arene Hydrogenation Catalysts: Synthesis, Reactions under Batch and Flow Conditions and Reaction Mechanism
Miyamura, Hiroyuki,Suzuki, Aya,Yasukawa, Tomohiro,Kobayashi, Shu
, p. 11325 - 11334 (2018/09/06)
Hydrogenation of arenes is an important ...
120014-30-4 Process route
-
-
120014-07-5,145546-80-1
1-benzyl-4-<(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methyl>piperidine
-
-
120014-06-4,142057-79-2,142057-80-5,142698-19-9
donepezil
-
-
120014-30-4
debenzyldonepezil
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran;
at 0 - 2 ℃;
for 1.5h;
under 760.051 Torr;
|
|
|
With
hydrogen;
palladium 10% on activated carbon;
In
toluene;
at 0 - 1 ℃;
for 5h;
under 6000.6 - 7500.75 Torr;
|
-
-
4803-57-0
2-(pyridin-4-yl)methyl-5,6-dimethoxy-1-indanone
-
-
120014-30-4
debenzyldonepezil
Conditions
| Conditions | Yield |
|---|---|
|
With
hydrogen;
platinum(IV) oxide;
In
methanol; acetic acid;
at 20 ℃;
for 6h;
under 2311.54 Torr;
|
99% |
|
With
palladium on activated charcoal; hydrogen; acetic acid;
In
methanol;
|
74% |
|
With
5% Pd(II)/C(eggshell); hydrogen; sodium acetate; acetic acid;
In
methanol; dichloromethane;
at 70 - 75 ℃;
for 10h;
under 4413.43 - 5149.01 Torr;
|
70% |
120014-30-4 Upstream products
-
877606-65-0
(E)-5, 6-dimethoxy-2-(pyridin-4-ylmethylene)-2, 3-dihydro-1H-inden-1-one
-
872-85-5
pyridine-4-carbaldehyde
-
2107-69-9
5,6-dimethoxy-1-indanone
-
861675-47-0
5,6-dimethoxy-2-(4-piperidinylmethyl)-indan-1-one acetate
120014-30-4 Downstream products
-
844694-85-5
1,1-dibenzyl-4-(5,6-dimethoxy-1-oxo-indan-2-ylmethyl)-piperidinium; bromide
-
120014-06-4
donepezil
-
142057-77-0
donepezil hydrochloride
-
1033718-29-4
ethyl 3-((4-((5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl)piperidin-1-yl)methyl)benzoate
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