- CasNo 545445-44-1
- Purity 99%
Location:Home > Pharmaceutical
3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
Factory Sells Best Quality 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 545445-44-1 with stock
- Molecular Formula: C20H25N3O3
- Molecular Weight: 355.437
- Boiling Point: 624.979 °C at 760 mmHg
- PKA: 3.25±0.20(Predicted)
- Flash Point: 331.775 °C
- PSA： 53.09000
- Density: 1.267 g/cm3
- LogP: 2.22420
545445-44-1 Relevant articles
Preparation method of apixaban intermediate suitable for industrial production
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Paragraph 0034; 0036; 0042, (2021/08/19)
The invention discloses a synthesis meth...
Preparation method of dihydropyridone derivatives
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Paragraph 0059-0063; 0069; 0073-0077; 0082-0086; 0091-0095, (2020/05/30)
The invention belongs to the technical f...
Apixaban intermediate and preparation method thereof
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Page/Page column 9-14, (2020/05/01)
The embodiment of the invention disclose...
Simple preparation method of 5,6-dihydropyridine-2 (1H)-one derivative
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, (2020/06/17)
The invention provides a simple and conv...
545445-44-1 Process route
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1575-61-7
5-Chlorovaleroyl chloride
-
-
1267610-26-3
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one
-
![5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone](/upload/2026/6/25229f09063e49188d4163895777a47b_a7f96f01-85a1-406d-9ac8-da4bdddc2c9d.png)
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545445-44-1
5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone
Conditions
| Conditions | Yield |
|---|---|
|
5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
tetrabutylammomium bromide; sodium hydroxide;
In
dichloromethane; water;
at 0 - 5 ℃;
for 1h;
With
potassium hydroxide;
In
dichloromethane; water;
at 20 ℃;
Reagent/catalyst;
Solvent;
Temperature;
|
94.27%
|
|
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
tetraethylammonium hydroxide;
In
1,2-dichloro-ethane;
at 0 ℃;
for 0.166667h;
5-Chlorovaleroyl chloride;
In
1,2-dichloro-ethane;
at 0 - 85 ℃;
for 5h;
Solvent;
Temperature;
Reagent/catalyst;
|
89%
|
|
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
sodium hydroxide;
In
acetonitrile;
at 0 ℃;
for 0.166667h;
Green chemistry;
5-Chlorovaleroyl chloride;
In
acetonitrile;
at 0 - 30 ℃;
for 5h;
Reagent/catalyst;
Solvent;
Temperature;
Green chemistry;
|
87.5%
|
|
5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
triethylamine;
In
tetrahydrofuran;
at 0 - 5 ℃;
for 0.5h;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 - 25 ℃;
for 2.5h;
|
86.8%
|
|
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
triethylamine;
In
dichloromethane;
for 0.0833333h;
5-Chlorovaleroyl chloride;
In
dichloromethane;
Solvent;
Reagent/catalyst;
|
83.2%
|
|
5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
triethylamine;
In
tetrahydrofuran;
at 0 - 40 ℃;
for 1h;
With
sodium hydride;
In
tetrahydrofuran;
at 10 - 40 ℃;
for 3h;
|
72%
|
|
5-Chlorovaleroyl chloride; 1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one;
With
triethylamine;
In
dichloromethane;
at 10 - 30 ℃;
for 1h;
Cooling with ice;
With
sodium ethanolate;
In
dichloromethane;
at 10 - 30 ℃;
for 2h;
|
5.2 g
|
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![5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide](/upload/2026/6/3c1ba5845434481688208affdf18c3fe_5cf36358-dcfb-4da4-ba2b-46ee2ccc47e8.png)
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1643330-62-4
5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide
-
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545445-44-1
5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone
Conditions
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
water;
at 20 - 30 ℃;
for 3h;
|
88%
|
|
With
sodium hydride;
In
tetrahydrofuran;
at 10 - 25 ℃;
Inert atmosphere;
|
84.5%
|
|
With
potassium tert-butylate;
In
tetrahydrofuran;
at 5 - 50 ℃;
for 8.5h;
Inert atmosphere;
|
3.02 g
|
545445-44-1 Upstream products
-
473927-69-4
1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one
-
675-20-7
piperidin-2-one
-
1267610-26-3
1-(4-aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one
-
1643330-62-4
5-chloropentanoic acid [4-(5-morpholin-4-yl-6-oxo-3,6-dihydro-2H-pyridin-1-yl)phenyl]amide
545445-44-1 Downstream products
-
503614-91-3
1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
-
503614-92-4
1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid
-
1620494-29-2
1-(4-benzyloxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester
-
1609409-53-1
ethyl {5-hydroxy-6-oxo-1-[4-(2-oxopiperidin-1-yl)phenyl]-1,2,3,6-tetrahydropyridin-4-yl}(oxo)acetate
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