Demeclocycline hydrochloride

CasNo 64-73-3
Purity 99%

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What is the Demeclocycline hydrochloride ?

Demeclocycline hydrochloride is Yellow solid, while it's Molecular Formula is C21H22Cl2N2O8. Demeclocycline hydrochloride is a salt prepared from demeclocycline taking advantage of the basic dimethylamino group which protonates and readily forms a salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis.

What is the CAS number for Demeclocycline hydrochloride ?

The CAS number of Demeclocycline hydrochloride is 64-73-3.

More information of Demeclocycline hydrochloride 64-73-3 are:

Synonyms	2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride (8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-;6-Demethyl-7-chlorotetracyclinehydrochloride;7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamidemonohydrochloride;7-Chloro-6-demethyltetracycline hydrochloride;Clortetrin;Declomycin;Declomycin hydrochloride;Demeclocycline hydrochloride;Demethylchlorotetracycline hydrochloride;Demetraciclina;Detravis;Ledermycinhydrochloride;Meciclin;
CAS?Number	64-73-3
Molecular Formula	C21H22Cl2N2O8
Molecular Weight	501.32
Melting Point	>245 °C (dec.)
Boiling Point	795.9 °C at 760 mmHg
Flash Point	435.2 °C
HS CODE	29413020
PSA	181.62000
LogP	1.76720
Pka	pKa 3.3 (Uncertain)

What is Demeclocycline hydrochloride (64-73-3) used for?

Demeclocycline lacks the C-6-methyl of tetracycline and is produced by a genetically altered strain of Streptomyces aureofaciens. Because it is a secondary alcohol, it is more chemically stable than tetracycline against dehydration. Food and milk co-consumption decrease absorption by half, although it is 60 to 80% absorbed by fasting adults. It is the tetracycline most highly associated with phototoxicity and has been shown to produce dose-dependent, reversible diabetes insipidus with extended use.

InChI:InChI=1/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6?,7?,14?,15-,21?;/m0./s1

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